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Levels of angiogenic factors in pregnancy and post-partum bleeding

Content Provider	Scilit
Author	Eskild, Anne Jeansson, Stig Jenum, Pål A. Staff, Anne C. Thadhani, Ravi Karumanchi, Ananth Vatten, Lars J.
Copyright Year	2008
Description	Journal: Acta Obstetricia et Gynecologica Scandinavica We have studied if serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) in pregnancy could predict excess post-partum bleeding. In 392 normotensive singleton pregnancies, concentrations of sFlt-1 and PlGF in the first, second, and third trimester were compared between women with and without excess post-partum bleeding, defined as blood loss volume of at least 500 mL. Mean concentrations of sFlt-1 were consistently higher in all three trimesters among women who had excess post-partum bleeding compared to women without this, but significantly higher only in the second trimester. For PlGF, there were no significant differences between the groups. High concentrations of the anti-angiogenic factor sFlt-1 in maternal circulation during pregnancy may be associated with an increased risk of excess post-partum bleeding.
Ending Page	1083
Starting Page	1081
ISSN	00221295
e-ISSN	16000412
DOI	10.1080/00016340802415622
Journal	Acta Obstetricia et Gynecologica Scandinavica
Issue Number	10
Volume Number	87
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-01-01
Access Restriction	Open
Subject Keyword	Journal: Acta Obstetricia et Gynecologica Scandinavica Obstetrics and Gynecology Angiogenic Factors Soluble Fms-like Tyrosine Kinase-1 (sflt-1)
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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