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Novel Neuroprotective Tripeptides and Dipeptides
| Content Provider | Scilit |
|---|---|
| Author | Faden, Alan I. Knoblach, Susan M. Movsesyan, Vilen A. Lea, Paul M. Cernak, Ibolja |
| Copyright Year | 2008 |
| Description | Journal: Annals of the New York Academy of Sciences It has long been recognized that thyrotropin-releasing hormone (TRH) and certain TRH analogues are neuroprotective in a variety of animal models of CNS trauma. In addition to these neuroprotective actions, TRH and most TRH analogues have other physiological actions that may not be desirable for treatment of acute injury, such as analeptic, autonomic, and endocrine effects. We have developed a series of dual-substituted TRH analogues that have strong neuroprotective actions, but are largely devoid of these other physiological actions. In addition, we have developed a family of cyclized dipeptides (diketopiperazines), structurally somewhat related to a metabolic product of TRH, that appear even more effective as neuroprotective agents in vitro and in vivo, and may have nootropic properties. Here, we review these novel tripeptide and dipeptide compounds. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2005.tb00057.x/pdf |
| Ending Page | 481 |
| Page Count | 10 |
| Starting Page | 472 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.2005.tb00057.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 1053 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-06-28 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Medicinal Chemistry |
| Content Type | Text |
| Resource Type | Article |
