Loading...
Please wait, while we are loading the content...
Similar Documents
Admission Heart Rate Predicts Mortality Following Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction: An Observational Study
| Content Provider | Scilit |
|---|---|
| Author | Noman, Awsan Balasubramaniam, Karthik Das, Rajiv Ang, Donald Kunadian, Vijay Ivanauskienė, Taida Zaman, Azfar G. |
| Copyright Year | 2013 |
| Description | Journal: Cardiovascular Therapeutics The prognostic value of admission heart rate (HR) on long-term mortality in ST-elevation myocardial infarction (STEMI) remains uncertain in the modern era of primary percutaneous coronary intervention (PPCI). This study aimed to assess the predictive value of admission HR on long-term mortality following PPCI and the influence of beta-blockers on postdischarge survival. Retrospective analysis of prospectively collected data on 2310 PPCI-treated STEMI patients at a regional tertiary center between March 2008 and June 2010. Patients were classified according to admission HR into either low (≤70 beat per minute [bpm], n = 1015) or high HR group (>70 bpm, n = 1295). At a median follow-up of 559 days, all-cause mortality was 7.0% in the low HR group compared to 12.7% in the high-HR group. In the Cox proportional hazard model, adjusted for several confounders, the hazard ratio (95% confidence interval) for all-cause mortality in the high HR group was 1.59 (1.15-2.20; P = 0.005). Every 10-bpm increase in admission HR was associated with 17% increase in all-cause mortality. Beta-blockers on discharge was associated with a reduction in postdischarge mortality only in the high HR group (adjusted hazard ratio, 0.49 [0.31-0.77; P = 0.002]), but not in the low HR group (adjusted hazard ratio, 0.74 [0.37-1.49; P = 0.33]). Elevated admission heart rate in PPCI-treated STEMI patients is associated with long-term all-cause mortality. Beta blocker therapy improved postdischarge survival in patients with elevated admission heart rate. |
| Ending Page | 369 |
| Starting Page | 363 |
| ISSN | 2573508X |
| e-ISSN | 17555922 |
| DOI | 10.1111/1755-5922.12031 |
| Journal | Cardiovascular Therapeutics |
| Issue Number | 6 |
| Volume Number | 31 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2013-11-27 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cardiovascular Therapeutics Cardiology and Cardiovascular Diseases Primary Percutaneous Coronary Intervention St‐elevation Myocardial Infarction Heart Rate Beta Blocker |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) Cardiology and Cardiovascular Medicine |
