NDLI: AMPA receptor subunits define properties of state-dependent synaptic plasticity

Please wait, while we are loading the content...

AMPA receptor subunits define properties of state-dependent synaptic plasticity

Content Provider	Scilit
Author	Emond, Michelle R. Montgomery, Johanna M. Huggins, Matthew L. Hanson, Jesse E. Mao, Lifang Huganir, Richard L. Madison, Daniel V.
Copyright Year	2010
Description	Journal: The Journal of physiology Many synapses undergo immediate and persistent activity-dependent changes in strength via processes that fall under the umbrella of synaptic plasticity. It is known that this type of synaptic plasticity exhibits an underlying state dependence; that is, as synapses change in strength they move into distinct 'states' that are defined by the mechanism and ability to undergo future plasticity. In this study, we have investigated the molecular mechanisms that underlie state-dependent synaptic plasticity. Using intracellular application of peptides that mimic the C-terminal tail sequences of GluR1 and GluR2 AMPA receptor subtypes, combined with paired recordings of minimal synaptic connections, we have shown that AMPA receptor subtypes present in the membrane at a given time confer some properties of plasticity states. These data show that during synaptic plasticity, AMPA receptor subtypes are differentially stabilized by postsynaptic density proteins in or out of the postsynaptic membrane, and this differential synaptic expression of different AMPA receptor subtypes defines distinct synaptic states.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901981/pdf
Ending Page	1946
Page Count	18
Starting Page	1929
ISSN	00223751
e-ISSN	14697793
DOI	10.1113/jphysiol.2010.187229
Journal	The Journal of physiology
Issue Number	11
Volume Number	588
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-05-28
Access Restriction	Open
Subject Keyword	Journal: The Journal of physiology Biochemistry and Molecular Biology Ampa Receptor Subtypes Peptides That Mimic Dependent Synaptic Plasticity
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in