NDLI: Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to $CO

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Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to $CO_{2}$

Content Provider	Scilit
Author	Ms, Binu P. Thomas Yezhuvath, Uma S. Tseng, Benjamin Y. Liu, Peiying Levine, Benjamin D. Zhang, Rong Lu, Hanzhang
Copyright Year	2013
Description	Journal: Journal of Magnetic Resonance Imaging (JMRI) Purpose To examine the potential benefits of life‐long aerobic exercise on brain health, in particular cerebrovascular function. Materials and Methods Ten Masters athletes (MA) (seven males, three females; 74.5 ± 5.8 years) and 10 sedentary elderly individuals (SE) (eight males, two females; 75.4 ± 5.6 years) were recruited and baseline cerebral blood flow (CBF) and cerebral vascular reactivity (CVR) to $CO_{2}$ were measured on a 3T MRI scanner. Nine sedentary young subjects were also recruited to serve as a control group to verify the age effect. Results When compared to the SE group, MA showed higher CBF in posterior cingulate cortex/precuneus, which are key regions of the default‐mode‐network and are known to be highly sensitive to age and dementia. CVR in the MA brains were paradoxically lower than that in SE. This effect was present throughout the brain. Within the MA group, individuals with higher $VO_{2max}$ had an even lower CVR, suggesting a dose–response relationship. Conclusion Life‐long aerobic exercise preserved blood supply in the brain's default‐mode‐network against age‐related degradation. On the other hand, its impact on the cerebral vascular system seems to be characterized by a dampening of $CO_{2}$ reactivity, possibly because of desensitization effects due to a higher lifetime exposure. J. Magn. Reson. Imaging 2013;38:1177–1183.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695025/pdf
Ending Page	1183
Page Count	7
Starting Page	1177
e-ISSN	15222586
DOI	10.1002/jmri.24090
Journal	Journal of Magnetic Resonance Imaging (JMRI)
Issue Number	5
Volume Number	38
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-03-22
Access Restriction	Open
Subject Keyword	Journal: Journal of Magnetic Resonance Imaging (JMRI) Radiology, Nuclear Medicine and Imaging Cerebral Vascular Reactivity Cerebral Blood Flow Arterial‐spin‐labeling
Content Type	Text
Resource Type	Article

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