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Use of CA-125 response to predict survival parameters of patients with advanced ovarian carcinoma
| Content Provider | Scilit |
|---|---|
| Author | Ron, Ilan-Gil Inbar, Moshe Gelernter, Ilana Lewysohn, Orly Ayalon, Daniel Dale, Janet Chaitchik, Samario |
| Copyright Year | 1994 |
| Description | Journal: Acta Obstetricia et Gynecologica Scandinavica The prognostic value of serum CA-125 levels both before chemotherapy and after each cycle of one or two courses was assessed in 48 patients with advanced ovarian adenocarcinoma. All patients received a minimum of six courses of either cyclophosphamide and cisplatinum (CAP) or cyclophosphamide, doxorubicin and cisplatinum (CAP). Patients with serum CA-125 values below the normal value of 35 U/ml after two courses had a significantly longer median survival (p <0.0001) and longer disease-free survival (p = 0.007) than did those patients whose CA-125 levels dropped to normal after the third or a later course of chemotherapy. A response in CA-125 levels after the first two courses of chemotherapy may indicate which patients should continue with the current chemotherapy regimen and which patients should he ol'fered salvage therapy. |
| Ending Page | 662 |
| Starting Page | 658 |
| ISSN | 00221295 |
| e-ISSN | 16000412 |
| DOI | 10.3109/00016349409013462 |
| Journal | Acta Obstetricia et Gynecologica Scandinavica |
| Issue Number | 8 |
| Volume Number | 73 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1994-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Obstetricia et Gynecologica Scandinavica Medical Laboratory Technology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
