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Meta-analysis: the efficacy of rectal beclomethasone dipropionate vs. 5-aminosalicylic acid in mild to moderate distal ulcerative colitis
| Content Provider | Scilit |
|---|---|
| Author | Manguso, F. Balzano, A. |
| Copyright Year | 2007 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Beclomethasone dipropionate (BDP) is a second-generation steroid with topical effects and minimal systemic activity for patients with ulcerative colitis (UC). To review all available literature to assess the efficacy of enema/foam BDP compared with enema/foam 5-aminosalicylic acid (5-ASA) in the control of left-sided mild-moderate UC. We selected randomized controlled trials of enema/foam BDP compared with enema/foam 5-ASA treatment in patients with UC. Two reviewers assessed trial quality and extracted data independently. Four trials involving 428 UC patients, 209 treated with 5-ASA (1-4 g o.d.) and 219 with BDP (3 mg o.d.), were included. Intention-to-treat analysis showed that 5-ASA induced improvement/remission of UC in 146 (69.9%) patients, while BDP in 143 (65.3%). The test for heterogeneity (Cochran Q) was not significant and Mantel-Haenszel pooled estimate of odds ratio was 1.23 (95% CI = 0.82-1.85). The results did not change when analysis was performed on a per-protocol basis. The randomized controlled trials identified in this review showed that rectal BDP has equal effect as 5-ASA to control symptoms in UC. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2007.03349.x/pdf |
| Ending Page | 29 |
| Page Count | 9 |
| Starting Page | 21 |
| e-ISSN | 13652036 |
| DOI | 10.1111/j.1365-2036.2007.03349.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 1 |
| Volume Number | 26 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2007-04-20 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Ulcerative Colitis Beclomethasone Dipropionate Aminosalicylic Acid Steroid with Topical |
| Content Type | Text |
| Resource Type | Article |
