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Review article: diagnosis and treatment of non-alcoholic fatty liver disease
| Content Provider | Scilit |
|---|---|
| Author | Oh, M. K. Winn, J. Poordad, F. |
| Copyright Year | 2008 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent condition affecting adults and children, leading to significant morbidity. It is often associated with the metabolic syndrome, although multiple pathogenetic mechanisms have been suggested. In the coming decades, it promises to be the leading cause of liver disease in industrial countries. To provide a comprehensive, updated review of diagnosis and management of NAFLD and to appraise the evolution of new modalities in these areas. An Ovid MEDLINE search was performed to identify pertinent original research and review articles. Selected references in these articles were also evaluated. The diagnosis of hepatic steatosis and steatohepatitis or non-alcoholic steatohepatitis (NASH) is not yet possible without liver biopsy. This is impractical given the large numbers affected by the condition. Current therapy has focused on improving insulin resistance and mediators of inflammation, factors probably associated with disease progression. There are no proven non-invasive diagnostic modalities to distinguish NAFLD and NASH, but new biomarker panels are approximating the liver biopsy in accuracy. Therapeutic targets of drug development are in early stages, but a multifaceted approach will probably yield several treatment options in the years to come. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2008.03752.x/pdf |
| Ending Page | 522 |
| Page Count | 20 |
| Starting Page | 503 |
| e-ISSN | 13652036 |
| DOI | 10.1111/j.1365-2036.2008.03752.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 5 |
| Volume Number | 28 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Insulin Resistance Metabolic Syndrome |
| Content Type | Text |
| Resource Type | Article |
