Applications of high-resolution magic angle spinning MRS in biomedical studies II-Human diseases

Content Provider	Scilit
Author	Dietz, Christopher Ehret, Felix Palmas, Francesco Vandergrift, Lindsey A. Jiang, Yanni Schmitt, Vanessa Dufner, Vera Habbel, Piet Nowak, Johannes Cheng, Leo L.
Copyright Year	2017
Description	Journal: NMR in Biomedicine High‐resolution magic angle spinning (HRMAS) MRS is a powerful method for gaining insight into the physiological and pathological processes of cellular metabolism. Given its ability to obtain high‐resolution spectra of non‐liquid biological samples, while preserving tissue architecture for subsequent histopathological analysis, the technique has become invaluable for biochemical and biomedical studies. Using HRMAS MRS, alterations in measured metabolites, metabolic ratios, and metabolomic profiles present the possibility to improve identification and prognostication of various diseases and decipher the metabolomic impact of drug therapies. In this review, we evaluate HRMAS MRS results on human tissue specimens from malignancies and non‐localized diseases reported in the literature since the inception of the technique in 1996. We present the diverse applications of the technique in understanding pathological processes of different anatomical origins, correlations with in vivo imaging, effectiveness of therapies, and progress in the HRMAS methodology.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690552/pdf
e-ISSN	10991492
DOI	10.1002/nbm.3784
Journal	NMR in Biomedicine
Issue Number	11
Volume Number	30
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2017-09-15
Access Restriction	Open
Subject Keyword	Journal: NMR in Biomedicine Microscopic Research High‐resolution Magic Angle Spinning (hrmas)
Content Type	Text
Resource Type	Article