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Vitamin D and Skin Cancer
| Content Provider | Scilit |
|---|---|
| Author | Burns, Erin M. Elmets, Craig A. Yusuf, Nabiha |
| Copyright Year | 2014 |
| Description | Journal: Photochemistry and Photobiology Vitamin D signaling plays a key role in many important processes, including cellular proliferation, differentiation and apoptosis, immune regulation, hormone secretion and skeletal health. Furthermore, vitamin D production and supplementation have been shown to exert protective effects via an unknown signaling mechanism involving the vitamin D receptor (VDR) in several diseases and cancer types, including skin cancer. With over 3.5 million new diagnoses in 2 million patients annually, skin cancer is the most common cancer type in the United States. While ultraviolet B (UVB) radiation is the main etiologic factor for nonmelanoma skin cancer (NMSC), UVB also induces cutaneous vitamin D production. This paradox has been the subject of contradictory findings in the literature in regards to amount of sun exposure necessary for appropriate vitamin D production, as well as any beneficial or detrimental effects of vitamin D supplementation for disease prevention. Further clinical and epidemiological studies are necessary to elucidate the role of vitamin D in skin carcinogenesis. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295013/pdf |
| Ending Page | 209 |
| Page Count | 9 |
| Starting Page | 201 |
| e-ISSN | 17511097 |
| DOI | 10.1111/php.12382 |
| Journal | Photochemistry and Photobiology |
| Issue Number | 1 |
| Volume Number | 91 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-12-08 |
| Access Restriction | Open |
| Subject Keyword | Journal: Photochemistry and Photobiology Medical Laboratory Technology Vitamin D Production |
| Content Type | Text |
| Resource Type | Article |
