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Differential actions of platelet-activating factor (PAF) receptor antagonists on the vasodilator and vasoconstrictor effects of PAF in the rat perfused heart
| Content Provider | Scilit |
|---|---|
| Author | Hu, Weimin |
| Copyright Year | 1991 |
| Description | Journal: British Journal of Pharmacology Selectivity for blocking the coronary vasodilator and vasoconstrictor effects of platelet-activating factor (PAF) in the rat perfused heart was observed with different PAF antagonists. CV-6209 showed selectivity for blocking the vasodilator effect of PAF and a higher concentration (10 fold) was required to block the vasoconstrictor effect. The remaining PAF antagonists (FR-900452, WEB 2086 and BN-50739) showed selectivity for blocking the vasoconstrictor effect of PAF (10, 200 and 1000 fold respectively). A combination of low concentrations of CV-6209 (10 nm) with FR-900452 (5 μm) or WEB 2086 (0.5 μm) was effective in blocking both the vasodilator and vasoconstrictor effects of PAF. CV-6209 and WEB 2086 did not affect the vasodilator action of leukotriene $B_{4}$ $(LTB_{4}$) and the vasoconstrictor action of $LTC_{4}$ and $LTD_{4}$. Our results support the hypothesis that the functionally opposite effects of PAF in the rat perfused heart may be mediated by different PAF receptor subtypes. |
| Related Links | http://europepmc.org/articles/pmc1908823?pdf=render https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1991.tb12504.x |
| Ending Page | 775 |
| Page Count | 3 |
| Starting Page | 773 |
| e-ISSN | 14765381 |
| DOI | 10.1111/j.1476-5381.1991.tb12504.x |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 104 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1991-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: British Journal of Pharmacology Paf Receptor Subtypes |
| Content Type | Text |
| Resource Type | Article |
