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The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs
| Content Provider | Scilit |
|---|---|
| Author | Fitzgerald, Mary F. Moncada, Salvador Parente, Luca |
| Copyright Year | 1986 |
| Description | Journal: British Journal of Pharmacology 1 The release of platelet-activating factor (Paf-acether) and of its inactive precursor/metabolite lysoplatelet activating factor (lyso-Paf) from control and sensitized guinea-pig isolated lungs challenged with antigen was investigated. 2 Control guinea-pig lungs perfused either through the pulmonary circulation or through the airways and challenged with antigen did not release Paf-acether. 3 Sensitized guinea-pig isolated lungs perfused through the pulmonary circulation and challenged with antigen released lyso-Paf but not Paf-acether. 4 Sensitized guinea-pig isolated lungs perfused through the airways and challenged with antigen released three times more lyso-Paf and also Paf-acether. 5 These results support a possible role for Paf-acether in respiratory anaphylaxis in the guinea-pig. |
| Related Links | http://europepmc.org/articles/pmc1917123?pdf=render https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1986.tb09481.x |
| Ending Page | 153 |
| Page Count | 5 |
| Starting Page | 149 |
| e-ISSN | 14765381 |
| DOI | 10.1111/j.1476-5381.1986.tb09481.x |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 88 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1986-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: British Journal of Pharmacology Activating Factor Guinea Pig |
| Content Type | Text |
| Resource Type | Article |
