NDLI: CD4 T Cells but Not Th17 Cells Are Required for Mouse Lung Transplant Obliterative Bronchiolitis

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CD4 T Cells but Not Th17 Cells Are Required for Mouse Lung Transplant Obliterative Bronchiolitis

Content Provider	Scilit
Author	Wu, Q. Gupta, P. K. Suzuki, H. Wagner, S. R. Zhang, C. Cummings, O. W. Fan, L. Kaplan, M. H. Wilkes, D. S. Shilling, R. A.
Copyright Year	2015
Description	Journal: American Journal of Transplantation Lung transplant survival is limited by obliterative bronchiolitis (OB), but the mechanisms of OB development are unknown. Previous studies in a mouse model of orthotopic lung transplantation suggested a requirement for IL-17. We have used this orthotopic mouse model to investigate the source of IL-17A and the requirement for T cells producing IL-17A. The major sources of IL-17A were CD4(+) T cells and γδ T cells. Depletion of CD4(+) T cells led to a significantly decreased frequency and number of IL-17A(+) lymphocytes and was sufficient to prevent acute rejection and OB. However, mice with STAT3-deficient T cells, which are unable to differentiate into Th17 cells, rejected lung allografts and developed OB similar to control mice. The frequency of IL-17A(+) cells was not decreased in mice with STAT3-deficient T cells due mainly to the presence of IL-17A(+) γδ T cells. Deficiency of γδ T cells also did not affect the development of airway fibrosis. Our data suggest that CD4(+) T cells are required for OB development and expansion of IL-17A responses in the lung, while Th17 and γδ T cells are not absolutely required and may compensate for each other.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679154/pdf
Ending Page	1804
Page Count	12
Starting Page	1793
e-ISSN	16006143
DOI	10.1111/ajt.13215
Journal	American Journal of Transplantation
Issue Number	7
Volume Number	15
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-03-13
Access Restriction	Open
Subject Keyword	Journal: American Journal of Transplantation Animal Models: Murine Basic (laboratory) Research/science Bronchiolitis Obliterans (bos) Lung (allograft) Function/dysfunction Lung Transplantation/pulmonology
Content Type	Text
Resource Type	Article

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