CAMTA1 is a novel tumour suppressor regulated by $miR-9/9^{*}$in glioblastoma stem cells

Content Provider	Scilit
Author	Schraivogel, Daniel Weinmann, Lasse Beier, Dagmar Tabatabai, Ghazaleh Eichner, Alexander Zhu, Jia Yun Anton, Martina Sixt, Michael Weller, Michael Beier, Christoph P. Meister, Gunter
Copyright Year	2011
Description	Journal: The EMBO Journal Cancer stem cells or cancer initiating cells are believed to contribute to cancer recurrence after therapy. MicroRNAs (miRNAs) are short RNA molecules with fundamental roles in gene regulation. The role of miRNAs in cancer stem cells is only poorly understood. Here, we report miRNA expression profiles of glioblastoma stem cell‐containing CD133+ cell populations. We find that miR‐9, miR‐9* (referred to as miR‐9/9*), miR‐17 and miR‐106b are highly abundant in CD133+ cells. Furthermore, inhibition of miR‐9/9* or miR‐17 leads to reduced neurosphere formation and stimulates cell differentiation. Calmodulin‐binding transcription activator 1 (CAMTA1) is a putative transcription factor, which induces the expression of the anti‐proliferative cardiac hormone natriuretic peptide A (NPPA). We identify CAMTA1 as an miR‐9/9* and miR‐17 target. CAMTA1 expression leads to reduced neurosphere formation and tumour growth in nude mice, suggesting that CAMTA1 can function as tumour suppressor. Consistently, CAMTA1 and NPPA expression correlate with patient survival. Our findings could provide a basis for novel strategies of glioblastoma therapy.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199389/pdf
Ending Page	4322
Page Count	14
Starting Page	4309
ISSN	02614189
e-ISSN	14602075
DOI	10.1038/emboj.2011.301
Journal	The EMBO Journal
Issue Number	20
Volume Number	30
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-08-19
Access Restriction	Open
Subject Keyword	Journal: The EMBO Journal Cancer Stem Cells Tumour Suppressor
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology