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Two-day ‘weekend’ lansoprazole-quadruple therapy for Helicobacter pylori infection
| Content Provider | Scilit |
|---|---|
| Author | Boer, W. A. De Etten, R. J. X. M. Van Coremans, A. Schneeberger, P. M. |
| Copyright Year | 1998 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Background: The very high cure rate of 1‐week quadruple therapy offers an opportunity to study a shorter treatment duration. This is needed to construct a time–response curve for the regimen. Methods: Fifty‐two patients with endoscopically proven H. pylori infection received lansoprazole 30 mg b.d., tripotassium dicitrato bismuthate 120 mg q.d.s., tetracycline 500 mg q.d.s. and metronidazole 500 mg q.d.s., following 3 days of lansoprazole pre‐treatment. A second endoscopy was performed at least 6 weeks later. A patient was cured if histology, CLO‐test, and culture of antrum and corpus were negative. Results: We achieved an intention‐to‐treat cure rate of 30/50 (60%, 95% CI: 46–73%) and a per protocol cure rate of 30/48 (63%, 95% CI: 48–75%). Cure rate in metronidazole‐sensitive strains was 24/37 (65%, 95% CI: 48–79%) and 2/5 (40%) in resistant strains. All patients that failed the regimen had a metronidazole‐resistant strain post‐treatment. Compliance was excellent and moderate or severe side‐effects occurred in only 4% of patients. Conclusion: A 2‐day 'weekend' quadruple therapy cures only 60% of patients and cannot be recommended, but these findings provide an insight into the mode of action of quadruple therapy. |
| Related Links | https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2036.1998.00266.x |
| Ending Page | 81 |
| Page Count | 5 |
| Starting Page | 77 |
| e-ISSN | 13652036 |
| DOI | 10.1046/j.1365-2036.1998.00266.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 1 |
| Volume Number | 12 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1998-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Quadruple Therapy |
| Content Type | Text |
| Resource Type | Article |
