Loading...
Please wait, while we are loading the content...
Similar Documents
No association of genetic variants inBDNFwith major depression: A meta- and gene-based analysis
| Content Provider | Scilit |
|---|---|
| Author | Gyekis, Joseph P. Yu, Weihong Dong, Shuqian Wang, Haina Qian, Jun Kota, Pravina Yang, Jingyun |
| Copyright Year | 2012 |
| Description | Journal: Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) Major depressive disorder (MDD) is a complex psychiatric condition with strong genetic predisposition. The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting. In this study, we performed a systematic literature search and conducted random‐effects meta‐analysis to evaluate genetic variants in BDNF with MDD. A gene‐based analysis was also conducted to investigate the cumulative effects of genetic polymorphisms in BDNF. A total of 28 studies from 26 published articles were included in our analysis. Meta‐analysis yielded an estimated odds ratio (OR) of 0.96 (95% CI: 0.89–1.05; P = 0.402) for Val66Met (rs6265), 0.83 (95% CI: 0.67–1.04; P = 0.103) for 11757C/G, 1.16 (95% CI: 0.74–1.82; P = 0.527) for 270T/C, 1.03 (95% CI: 0.18–5.75; P = 0.974) for 712A/G and 0.98 (95% CI: 0.85–1.14; P = 0.831) for rs988748. The gene‐based analysis indicated that BDNF is not associated with MDD (P > 0.21). Our updated meta‐ and novel gene‐based analyses provide no evidence of the association of BDNF with major depression. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725128/pdf |
| Ending Page | 70 |
| Page Count | 10 |
| Starting Page | 61 |
| e-ISSN | 1552485X |
| DOI | 10.1002/ajmg.b.32122 |
| Journal | Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) |
| Issue Number | 1 |
| Volume Number | 162 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-11-26 |
| Access Restriction | Open |
| Subject Keyword | Journal: Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) Psychiatry and Mental Health Major Depressive Disorder Gene‐based Analysis |
| Content Type | Text |
| Resource Type | Article |
