Serial Action Potential Analysis in Guillain-Barré Syndrome

Content Provider	Scilit
Author	Takahashi, Kazuro Nakashima, Kenji
Copyright Year	1981
Description	Journal: Psychiatry and clinical neurosciences Action potential analyses were carried out in 62 skeletal muscles of 16 patients with the Guillain-Barré syndrome. The muscles of a good prognosis showed only a slight change in duration, amplitude and phase of action potentials on electromyograms. On the other hand, the muscles of a poor prognosis showed a marked increase in duration and amplitude of action potentials, especially in the chronic stage. The incidence of polyphasic potentials was more frequent in the early stage than in the chronic stage of the muscles of a poor prognosis. The changes in duration in the early stage of a poor prognosis muscles were similar to those of acute beriberi neuropathy and the changes in the later stage were similar to those of amyotrophic lateral sclerosis, both of which showed axonal degenerations. In the early stage, myopathy-like changes in electromyography were often noticed, but the muscle biopsy showed only early neurogenic changes. Coupling or satellite discharges were found most frequently six or eight months after the onset, and decreased in number in the chronic stage. Satellites with blockings appeared earlier than those without blockings. A poor prognosis might be induced by an axonal degeneration partly together with segmental demyelinations.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1819.1981.tb00249.x/pdf
Ending Page	520
Page Count	10
Starting Page	511
e-ISSN	14401819
DOI	10.1111/j.1440-1819.1981.tb00249.x
Journal	Psychiatry and clinical neurosciences
Issue Number	4
Volume Number	35
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1981-12-01
Access Restriction	Open
Subject Keyword	Journal: Psychiatry and clinical neurosciences Cell Tissue Engineering Guillain‐barré Syndrome Segmental Demyelination Axonal Degeneration
Content Type	Text
Resource Type	Article