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CD36 in Atherosclerosis: The Role of a Class B Macrophage Scavenger Receptor
| Content Provider | Scilit |
|---|---|
| Author | Nicholson, Andrew C. Febbraio, Maria Han, Jihong Silverstein, Roy L. Hajjar, David P. |
| Copyright Year | 2006 |
| Description | Journal: Annals of the New York Academy of Sciences CD36, an 88 kD transmembrane glycoprotein, is an important receptor for oxidized lipoproteins. Unlike the LDL receptor, expression of CD36 is upregulated by this pro‐atherogenic particle, and binding and uptake perpetuates a cycle of lipid accumulation and receptor expression. This effect is, in part, mediated by the transcription factor, peroxisome proliferator activated receptor‐γ (PPARγ), and its ligands. We have found that specific inhibitors of protein kinase C (PKC) reduce basal mRNA expression of CD36 and block induction of CD36 mRNA and protein by oxidized LDL (OxLDL) and a PPARγ ligand. In addition, PKC inhibitors block both PPARγ mRNA and protein expression. These results suggest that activation of CD36 gene expression by OxLDL involves activation and translocation of PKC with subsequent PPARγ activation. More recently, we have generated a mouse null for CD36, and crossed it with the atherogenic Apo E null strain. Evaluation of lesion development in these animals will allow us to assess the in vivo contribution of CD36 to the pathogenesis of atherosclerosis. |
| Related Links | https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2000.tb06307.x |
| Ending Page | 133 |
| Page Count | 6 |
| Starting Page | 128 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.2000.tb06307.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 902 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2006-01-25 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Biochemistry and Molecular Biology Scavenger Receptor |
| Content Type | Text |
| Resource Type | Article |
