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New Designs for Phototherapeutic Transition Metal Complexes
| Content Provider | Scilit |
|---|---|
| Author | Imberti, Cinzia Zhang, Pingyu Huang, Huaiyi Sadler, Peter J. |
| Copyright Year | 2019 |
| Description | Journal: Angewandte Chemie International Edition In this Minireview, we highlight recent advances in the design of transition metal complexes for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the challenges and opportunities for the translation of such agents into clinical use. New designs for light-activated transition metal complexes offer photoactivatable prodrugs with novel targeted mechanisms of action. Light irradiation can provide spatial and temporal control of drug activation, increasing selectivity and reducing side-effects. The photophysical and photochemical properties of transition metal complexes can be controlled by the appropriate choice of the metal, its oxidation state, the number and types of ligands, and the coordination geometry. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973108/pdf |
| Ending Page | 73 |
| Page Count | 13 |
| Starting Page | 61 |
| ISSN | 14337851 |
| e-ISSN | 15213773 |
| DOI | 10.1002/anie.201905171 |
| Journal | Angewandte Chemie International Edition |
| Issue Number | 1 |
| Volume Number | 59 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2020-01-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Angewandte Chemie International Edition Inorganic Chemistry Metal Complexes Photoactivated Chemotherapy Photodynamic Therapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Catalysis |
