NDLI: Nicotinic Stimulation of $[^{3}$H]Acetylcholine Release from Mouse Cerebral Cortical Synaptosomes

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Nicotinic Stimulation of $[^{3}$H]Acetylcholine Release from Mouse Cerebral Cortical Synaptosomes

Content Provider	Scilit
Author	Rowell, Peter P. Winkler, Donald L.
Copyright Year	1984
Description	Journal: Journal of Neurochemistry The effects of nicotine and 1,1-dimethyl-4-phenylpiperazinium (DMPP) on the release of newly synthesized [3H]acetylcholine in mouse cerebral cortical synaptosomes were examined. Nicotine and DMPP produced increases in [3H]acetylcholine release, over the level of spontaneous release, of 24% and 30%, respectively, of a maximum depolarization-induced release produced by 50 mM potassium. The maximum effect was achieved at a concentration of 1 X 10(-4) M for both agents. The time course of release indicated a slow onset of action, reaching a maximum effect at 15 min of incubation. Both nicotine and DMPP also produced a slightly greater release of total tritium, measured in the absence of cholinesterase inhibition, than of [3H]acetylcholine. The release induced by nicotine was completely antagonized by hexamethonium and was largely (58%) calcium-dependent. Nicotine also produced an increase in [3H]choline accumulation into synaptosomes. These results indicate that the nicotinic agonists nicotine and DMPP can produce a moderate enhancement of acetylcholine release by a receptor-mediated action on cholinergic nerve terminals in the central nervous system.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1984.tb06083.x/pdf
Ending Page	1598
Page Count	6
Starting Page	1593
e-ISSN	14714159
DOI	10.1111/j.1471-4159.1984.tb06083.x
Journal	Journal of Neurochemistry
Issue Number	6
Volume Number	43
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1984-12-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Neurochemistry Acetylcholine Release
Content Type	Text
Resource Type	Article

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