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Effects ofClinacanthus siamensisleaf extract on influenza virus infection
| Content Provider | Scilit |
|---|---|
| Author | Wirotesangthong, Mali Nagai, Takayuki Yamada, Haruki Amnuoypol, Surattana Mungmee, Chutichot |
| Copyright Year | 2008 |
| Description | Journal: Microbiology and Immunology Ethanolic extracts of 20 medicinal plants were screened for influenza virus NA inhibition and in vitro antiviral activities using MDCK cells in an MTT assay. The vaccine proteins of influenza virus A/New Caledonia/20/99 (H1N1), mouse‐adapted influenza virus A/Guizhou/54/89 (A/G)(H3N2) and mouse‐adapted influenza virus B/Ibaraki/2/85 (B/I) were used in the NA inhibition assay, and mouse‐adapted influenza viruses A/PR/8/34 (H1N1), A/G and B/I were used in the in vitro antiviral assay. The results of the in vitro antiviral assay indicated that the A/G virus was the most susceptible and an extract of the leaf of CS possessed the highest in vitro anti‐A/G virus activity (41.98%). Therefore, the A/G virus and the CS extract were selected for studying in vivo anti‐influenza virus activity. BALB/c mice were treated with CS extract (100 mg/kg per day, 5 times) orally from 4 hr before to 4 days after infection. CS extract elicited significant production of anti‐influenza virus $IgG_{1}$ antibody in BAW and increased mouse weight compared to oseltamivir (0.1 mg/kg per day) on day 19 or water on days 17–19 of infection. Moreover, CS extract produced a higher anti‐influenza virus IgA antibody level in BAW compared to oseltamivir, and a tendency towards an increase in anti‐influenza virus IgA compared to water was shown. The results suggest that CS extract has a protective effect against influenza virus infection. |
| Related Links | https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1348-0421.2008.00095.x |
| Ending Page | 74 |
| Page Count | 9 |
| Starting Page | 66 |
| ISSN | 03855600 |
| e-ISSN | 13480421 |
| DOI | 10.1111/j.1348-0421.2008.00095.x |
| Journal | Microbiology and Immunology |
| Issue Number | 2 |
| Volume Number | 53 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-11-10 |
| Access Restriction | Open |
| Subject Keyword | Journal: Microbiology and Immunology Anti‐influenza Virus Activity Clinacanthus Siamensis Protective Effect Thai Medicinal Plant |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Immunology Microbiology |
