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Synergism of Environmental Carcinogens and Promoters on Bladder Cancer Development Initiated by N-Butyl-N-(4-hydroxybutyl)nitrosamine in F344 Rats
| Content Provider | Scilit |
|---|---|
| Author | Ono, Satoko Kurata, Yasushi Shichino, Yutaka Sano, Masashi Fukushima, Shoji |
| Copyright Year | 1992 |
| Description | Journal: Japanese Journal of Cancer Research Synergistic or additive effects of combined treatments with carcinogens or promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-initiated rat bladder carcinogenesis were examined. Male F344 rats were given BBN as an initiator followed by low doses of 3 sodium salts (sodium bicarbonate, sodium L-ascorbate and sodium citrate) and/or 3 antioxidants (butylated hydroxyanisole, butylated hydroxytoluene and tertiary butylhydroxyquinone). Combined treatments with 3 sodium salts or 3 antioxidants, and especially all 6 chemicals together promoted bladder carcinogenesis. In addition, these combined treatments were associated with increased DNA synthesis of the bladder epithelium. Combined administration of the carcinogens, o-anisidine, p-cresidine, and 4-chloro-o-phenylenediamine at low doses also enhanced BBN-initiated bladder carcinogenesis. These results indicate that environmental carcinogens or promoters can exert synergistic or additive actions on bladder cancer induction. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918976/pdf http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.1992.tb02007.x/pdf |
| Ending Page | 963 |
| Page Count | 9 |
| Starting Page | 955 |
| ISSN | 09105050 |
| DOI | 10.1111/j.1349-7006.1992.tb02007.x |
| Journal | Japanese Journal of Cancer Research |
| Issue Number | 9 |
| Volume Number | 83 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1992-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Japanese Journal of Cancer Research Rat Bladder Carcinogenesis Bladder Cancer Promoter Bladder Carcinogen Tumor Promotion |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
