NDLI: Brain parenchymal damage after haematopoietic stem cell transplantation for severe sickle cell disease

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Brain parenchymal damage after haematopoietic stem cell transplantation for severe sickle cell disease

Content Provider	Scilit
Author	Woodard, Paul Helton, Kathleen J. Khan, Raja B. Hale, Gregory A. Phipps, Sean Wang, Winfred Handgretinger, Rupert Cunningham, John M.
Copyright Year	2005
Description	Journal: British Journal of Haematology Prospective magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), neuropsychological testing and neurological examinations were performed to determine the long-term effect of successful haematopoietic stem cell transplantation on the neurological status of nine children with sickle cell disease. A scoring system for severity of brain parenchymal and vascular lesions was developed and applied. Neurological examinations and neuropsychometric tests were stable, but MRI and MRA studies were not. Transient changes occurred early in two patients. Persistent changes occurred in five. Parenchymal lesions occurred in zero of two patients without prior lacunae or infarcts and in all seven with prior lacunae or infarcts (P = 0.0278).
Ending Page	552
Starting Page	550
ISSN	2573508X
e-ISSN	13652141
DOI	10.1111/j.1365-2141.2005.05491.x
Journal	British Journal of Haematology
Issue Number	4
Volume Number	129
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2005-05-01
Access Restriction	Open
Subject Keyword	Journal: British Journal of Haematology Sickle Cell Disease Haematopoietic Stem Cell Transplantation Central Nervous System
Content Type	Text
Resource Type	Article

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