Emergence of Klebsiella pneumoniae carrying the novel extended-spectrum β-lactamase gene variants blaSHV-40, blaTEM-116 and the class 1 integronassociated blaGES-7 in Brazil

Content Provider	Scilit
Author	Dropa, M. Balsalobre, L. C. Lincopan, Nilton Mamizuka, E. M. Cassettari, V. C. Matté, G. R. Matté, M. H.
Copyright Year	2010
Description	Journal: Clinical Microbiology and Infection A clinical Klebsiella pneumoniae isolate carrying the extended-spectrum beta-lactamase gene variants bla(SHV-40), bla(TEM-116) and bla(GES-7) was recovered. Cefoxitin and ceftazidime activity was most affected by the presence of these genes and an additional resistance to trimethoprim-sulphamethoxazole was observed. The bla(GES-7) gene was found to be inserted into a class 1 integron. These results show the emergence of novel bla(TEM) and bla(SHV) genes in Brazil. Moreover, the presence of class 1 integrons suggests a great potential for dissemination of bla(GES) genes into diverse nosocomial pathogens. Indeed, the bla(GES-7) gene was originally discovered in Enterobacter cloacae in Greece and, to our knowledge, has not been reported elsewhere.Collaborating Center of Sanitary Surveillance (CECOVISA - School of Public Health, University of Sao Paulo
Ending Page	632
Starting Page	630
ISSN	2573508X
e-ISSN	14690691
DOI	10.1111/j.1469-0691.2009.02944.x
Journal	Clinical Microbiology and Infection
Issue Number	6
Volume Number	16
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-06-01
Access Restriction	Open
Subject Keyword	Journal: Clinical Microbiology and Infection Infectious Diseases Class 1 Integron Extended‐spectrum Β‐lactamase Klebsiella Pneumoniae Latin America
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Microbiology (medical)