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Zirconocene-Mediated Carbonylative Coupling of Grignard Reagents
| Content Provider | Scilit |
|---|---|
| Author | Moss, Melissa Han, Xinping Ready, Joseph M. |
| Copyright Year | 2016 |
| Description | Journal: Angewandte Chemie International Edition Organozirconocenes are versatile synthetic intermediates that can undergo carbonylation to yield acyl anion equivalents. Zirconocene hydrochloride ([Cp2 ZrHCl]) is often the reagent of choice for accessing these intermediates but generates organozirconocenes only from alkenes and alkynes. This requirement eliminates a broad range of substrates. For example, organozirconocenes in which the zirconium center is bonded to an aromatic ring, a benzylic group, or an alkyl group that possesses a tertiary or quaternary carbon atom α to the carbon-zirconium bond can not be formed in this way. To provide more generalized access to acyl zirconium reagents, we explored the transmetalation of Grignard reagents with zirconocene dichloride under a CO atmosphere. This protocol generates acyl zirconium(IV) complexes that are inaccessible with the Schwartz reagent, including those derived from secondary and tertiary alkyl and aryl Grignard reagents. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980256/pdf |
| Ending Page | 10021 |
| Page Count | 5 |
| Starting Page | 10017 |
| ISSN | 14337851 |
| e-ISSN | 15213773 |
| DOI | 10.1002/anie.201603133 |
| Journal | Angewandte Chemie International Edition |
| Issue Number | 34 |
| Volume Number | 55 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2016-07-13 |
| Access Restriction | Open |
| Subject Keyword | Journal: Angewandte Chemie International Edition Organic Chemistry Carbonylative Coupling Zirconium Complexes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Catalysis |
