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ERYTHROCYTE ANTIOXIDANT ENZYME ACTIVITIES IN CHILDREN WITH MYELOMENINGOCELE
| Content Provider | Scilit |
|---|---|
| Author | Graf, William D. Pippenger, C. E. Shurtleff, David B. |
| Copyright Year | 2008 |
| Description | Journal: Developmental Medicine and Child Neurology Erythrocyte free radical scavenging enzyme activities and their cofactor trace elements in plasma were assessed in 26 selected patients with myelomeningocele, both parents from 10 selected families, and 14 healthy adult controls. All index children except one were deficient in erythrocyte glutathione peroxidase (GSH-Px). Nine of 10 parent pairs had at least one parent with deficient GSH-Px activity. Children with myelomeningocele had significantly lower GSH-Px activities than their parents; the group of 10 parent pairs had significantly lower GSH-Px activities than the control group; and glutathione reductase activities were significantly lower in parents and children with myelomeningocele compared with controls. A deficiency in one or more antioxidant enzymes may increase the risk for neural tube defects. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.1995.tb11942.x/pdf |
| Ending Page | 905 |
| Page Count | 6 |
| Starting Page | 900 |
| ISSN | 00121622 |
| e-ISSN | 14698749 |
| DOI | 10.1111/j.1469-8749.1995.tb11942.x |
| Journal | Developmental Medicine and Child Neurology |
| Issue Number | 10 |
| Volume Number | 37 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-11-12 |
| Access Restriction | Open |
| Subject Keyword | Journal: Developmental Medicine and Child Neurology Pediatrics and Child Health Peripheral Vascular Disease Children with Myelomeningocele |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Pediatrics, Perinatology and Child Health Developmental Neuroscience |
