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High resolution spectroscopic imaging of GABA at 3 Tesla
| Content Provider | Scilit |
|---|---|
| Author | Zhu, He Edden, Richard A. E. Ouwerkerk, Ronald Barker, Peter B. |
| Copyright Year | 2010 |
| Description | Journal: Magnetic Resonance in Medicine A spin echo-based MRSI sequence was developed to acquire edited spectra of γ-aminobutyric acid in an entire slice. Water and lipid signals were suppressed by a dual-band presaturation sequence, which included integrated outer volume suppression pulses for additional lipid suppression. Experiments in three normal volunteers were performed at 3 T using a 32-channel head coil. High signal-to-noise ratio spectra and metabolic images of γ-aminobutyric acid were acquired from nominal 4.5 cm3 voxels (estimated actual voxel size 7.0 cm3) in a scan time of 17 min. The sequence is also expected to co-edit homocarnosine and macromolecules, giving a composite γ-aminobutyric acid+ resonance. The γ-aminobutyric acid+ to water ratio was measured using a companion water MRSI scan and was found to correlate linearly with the % gray matter (GM) of each voxel (γ-aminobutyric acid+/water=(1.5×GM+3.2)×10(-5), R=0.27), with higher γ-aminobutyric acid+ levels in gray matter compared with white. In conclusion, high signal-to-noise ratio γ-aminobutyric acid-MRSI is possible at 3 T within clinically feasible scan times. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154622/pdf |
| Ending Page | 609 |
| Page Count | 7 |
| Starting Page | 603 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.22671 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 3 |
| Volume Number | 65 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-11-04 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Magnetic Resonance Spectroscopic Imaging 3 Tesla |
| Content Type | Text |
| Resource Type | Article |
