Loading...
Please wait, while we are loading the content...
Similar Documents
Control of smooth muscle cell function by membrane-type matrix metalloproteinases.
| Content Provider | Scilit |
|---|---|
| Author | Shofuda, Ken-Ichi Hasenstab, David Shofuda, Tomoko Kenagy, Richard D. Clowes, Alexander W. |
| Copyright Year | 2006 |
| Description | Journal: Annals of the New York Academy of Sciences Vascular smooth muscle cells (SMCs) express membrane-type matrix metalloproteinases-1 and -3 (MT1- and MT3-MMPs). Expression is induced by PDGF in culture or by balloon injury in rat carotid arteries. In this study, we tried to define their functions in SMCs by transducing MT1- and MT3-MMP cDNAs into baboon-cultured SMCs, using adenoviral vectors. Overexpression of MT1-MMP increased the conversion of proMMP-2 to the activated form. In contrast, in MT3-MMP overexpressing cells, MMP-2 activation was partial. However, both MT1- and MT3-MMP overexpression elicited morphological alterations (cell rounding), which was prevented by BB94 addition. The cells, which underwent this change, showed reduced adhesion to matrices and increased migration in a Boyden chamber. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2001.tb03958.x/pdf |
| Ending Page | 340 |
| Page Count | 4 |
| Starting Page | 337 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.2001.tb03958.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 947 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2006-01-25 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Biochemistry and Molecular Biology Smooth Muscle Cells Matrix Metalloproteinases |
| Content Type | Text |
| Resource Type | Article |
