NDLI: Allergic Conjunctivitis Renders CD4+T Cells Resistant to T Regulatory Cells and Exacerbates Corneal Allograft Rejection

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Allergic Conjunctivitis Renders CD4+T Cells Resistant to T Regulatory Cells and Exacerbates Corneal Allograft Rejection

Content Provider	Scilit
Author	Reyes, Nancy J. Chen, Peter W. Niederkorn, Jerry Y.
Copyright Year	2013
Description	Journal: American Journal of Transplantation Allergic diseases rob corneal allografts of immune privilege and increase immune rejection. Corneal allograft rejection in BALB/c allergic hosts was analyzed using a short ragweed (SWR) pollen model of allergic conjunctivitis. Allergic conjunctivitis did not induce exaggerated T-cell responses to donor C57BL/6 (B6) alloantigens or stimulate cytotoxic T lymphocyte (CTL) responses. Allergic conjunctivitis did affect T regulatory cells (Tregs) that support graft survival. Exogenous IL-4, but not IL-5 or IL-13, prevented Treg suppression of CD4(+) effector T cells isolated from naïve mice. However, mice with allergic conjunctivitis developed Tregs that suppressed CD4(+) effector T-cell proliferation. In addition, IL-4 did not inhibit Treg suppression of IL-4Rα(-/-) CD4(+) T-cell responses, suggesting that IL-4 rendered effector T cells resistant to Tregs. SRW-sensitized IL-4Rα(-/-) mice displayed the same 50% graft survival as nonallergic WT mice, that was significantly less than the 100% rejection that occurred in allergic WT hosts, supporting the role of IL-4 in the abrogation of immune privilege. Moreover, exacerbation of corneal allograft rejection in allergic mice was reversed by administering anti-IL-4 antibody. Thus, allergy-induced exacerbation of corneal graft rejection is due to the production of IL-4, which renders effector T cells resistant to Treg suppression of alloimmune responses.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640580/pdf
Ending Page	1192
Page Count	12
Starting Page	1181
e-ISSN	16006143
DOI	10.1111/ajt.12198
Journal	American Journal of Transplantation
Issue Number	5
Volume Number	13
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-05-01
Access Restriction	Open
Subject Keyword	Journal: American Journal of Transplantation T Regulatory Cells
Content Type	Text
Resource Type	Article

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