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The$ ^{13}$ C-urea breath test to detect Helicobacter pylori infection: a validated simple methodology with 50 mg$ ^{13}$ C-urea
| Content Provider | Scilit |
|---|---|
| Author | Liao, C. -C. Lee, C. -L. Chiang, T. -C. Lee, S. -C. Huang, S. -H. Tu, T. -C. Chen, T. -K. Wu, C. -H. |
| Copyright Year | 2002 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Several modifications of the$ ^{13}$C-urea breath test have been published. For reasons of cost efficiency and practicability, the urea dose and measurement duration should be reduced while still maintaining excellent diagnostic accuracy. To establish a validated simple protocol for the urea breath test with 50 mg$ ^{13}$C-urea and to compare this protocol with the conventional urea breath test with 100 mg$ ^{13}$C-urea. Conventional urea breath test with 100 mg$ ^{13}$C-urea was performed on 152 dyspeptic patients. Full-cream cow's milk was used as the test meal. Breath tests were repeated using 50 mg$ ^{13}$C-urea and the breath samples were collected at baseline and at 10 (protocol $t_{10}$), 15 (protocol $t_{15}$) and 30 min (protocol $t_{30}$). Helicobacter pylori status was assessed by rapid urease test, histology and conventional urea breath test with 100 mg$ ^{13}$C-urea. With protocol $t_{15}$, the best combination of sensitivity (99.1%), specificity (97.3%) and accuracy (98.7%) was obtained with a cut-off of 2.5‰. There was an extremely high correlation coefficient between the three protocols and conventional$ ^{13}$C-urea breath test (all P < 0.001). A urea breath test with 50 mg$ ^{13}$C-urea using a simple test meal and a 15-min sampling interval with a low cut-off seems to be cost-effective and convenient. In a well-standardized laboratory, this modification is not associated with any loss of diagnostic accuracy. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2036.2002.01212.x/pdf |
| Ending Page | 792 |
| Page Count | 6 |
| Starting Page | 787 |
| e-ISSN | 13652036 |
| DOI | 10.1046/j.1365-2036.2002.01212.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 4 |
| Volume Number | 16 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2002-04-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Urea Breath Test |
| Content Type | Text |
| Resource Type | Article |
