The detection of mature T- and B-cells during development of the lymphoid tissues of the tammar wallaby (Macropus eugenii)

Content Provider	Scilit
Author	Deane, E. M.
Copyright Year	2003
Description	Journal: Journal of Anatomy The distribution of T- and B-cells in the developing lymphoid and immunohaematopoietic tissues of the tammar wallaby were investigated using antibodies to the mature cell surface markers, CD3, CD5 and CD79b. In the thymus, CD3- and CD5-positive T-cells were first observed at day 12 postpartum whilst rare B-cells were first detected at day 23. Both T- and B-lymphocytes were first stained on day 21 postpartum in the spleen and day 24 in lymph nodes. In one sample from a 7-day-old animal, rare CD79b-positive (CD79b+) lymphocytes were observed in the gut-associated lymphoid tissues. However, CD3+ cells were not apparent until day 12 and CD5+ cells were not detected until day 74 postpartum. No lymphocytes were detected in liver or bone marrow samples and no bronchus-associated lymphoid tissues were observed. The pattern of development and the distribution of T- and B-cells in the lymphoid and immunohaematopoietic tissues were similar to those observed in eutherian mammals and in limited studies of other metatherians. However, the detection of apparently mature T- and B-cells in the thymus and gut-associated lymphoid tissues (GALT) at the same postnatal age highlights the need for a more substantial study of the development of GALT. This is, at present, limited by availability of marsupial-specific antibodies.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571143/pdf http://onlinelibrary.wiley.com/doi/10.1046/j.1469-7580.2003.00207.x/pdf
Ending Page	131
Page Count	9
Starting Page	123
e-ISSN	14697580
DOI	10.1046/j.1469-7580.2003.00207.x
Journal	Journal of Anatomy
Issue Number	1
Volume Number	203
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2003-07-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Anatomy
Content Type	Text
Resource Type	Article