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Adoptive Transfer of Renal Allograft Tolerance in a Large Animal Model
| Content Provider | Scilit |
|---|---|
| Author | Villani, V. Yamada, K. Scalea, J. R. Gillon, B. C. Arn, J. S. Sekijima, M. Tasaki, M. Cormack, T. A. Moran, S. G. Torabi, R. Shimizu, A. Sachs, D. H. |
| Copyright Year | 2015 |
| Description | Journal: American Journal of Transplantation Our recent studies in an inbred swine model demonstrated that both peripheral and intra-graft regulatory cells were required for the adoptive transfer of tolerance to a second, naïve donor-matched kidney. Here, we have asked whether both peripheral and intra-graft regulatory elements are required for adoptive transfer of tolerance when only a long-term tolerant (LTT) kidney is transplanted. Nine highly-inbred swine underwent a tolerance-inducing regimen to prepare LTT kidney grafts which were then transplanted to histocompatible recipients, with or without the peripheral cell populations required for adoptive transfer of tolerance to a naïve kidney. In contrast to our previous studies, tolerance of the LTT kidney transplants alone was achieved without transfer of additional peripheral cells and without strategies to increase the number/potency of regulatory T cells in the donor. This tolerance was systemic, since most subsequent, donor-matched challenge kidney grafts were accepted. These results confirm the presence of a potent tolerance-inducing and/or tolerance-maintaining cell population within LTT renal allografts. They suggest further that additional peripheral tolerance mechanisms, required for adoptive transfer of tolerance to a naïve donor-matched kidney, depend on peripheral cells that, if not transferred with the LTT kidney, require time to develop in the adoptive host. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718904/pdf |
| Ending Page | 324 |
| Page Count | 8 |
| Starting Page | 317 |
| e-ISSN | 16006143 |
| DOI | 10.1111/ajt.13424 |
| Journal | American Journal of Transplantation |
| Issue Number | 1 |
| Volume Number | 16 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-08-10 |
| Access Restriction | Open |
| Subject Keyword | Journal: American Journal of Transplantation Urology and Nephrology Kidney (allograft) Function/dysfunction Tolerance: Experimental |
| Content Type | Text |
| Resource Type | Article |
