Loading...
Please wait, while we are loading the content...
Similar Documents
Whole-body magnetic resonance imaging evaluation of facioscapulohumeral muscular dystrophy
| Content Provider | Scilit |
|---|---|
| Author | Leung, Doris G. Carrino, John A. Wagner, Kathryn R. Jacobs, Michael A. |
| Copyright Year | 2015 |
| Description | Journal: Muscle & Nerve Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary disorder that causes progressive muscle wasting. Increasing knowledge of the pathophysiology of FSHD has stimulated interest in developing biomarkers of disease severity. Two groups of MRI scans were analyzed: whole-body scans from 13 subjects with FSHD; and upper and lower extremity scans from 34 subjects with FSHD who participated in the MYO-029 clinical trial. Muscles were scored for fat infiltration and edema-like changes. Fat infiltration scores were compared with muscle strength and function. The analysis revealed a distinctive pattern of both frequent muscle involvement and frequent sparing in FSHD. Averaged fat infiltration scores for muscle groups in the legs correlated with quantitative muscle strength and 10-meter walk times. Advances in MRI technology allow for acquisition of rapid, high-quality, whole-body imaging in diffuse muscle disease. This technique offers a promising disease biomarker in FSHD and other muscle diseases. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504833/pdf |
| Ending Page | 520 |
| Page Count | 9 |
| Starting Page | 512 |
| e-ISSN | 10974598 |
| DOI | 10.1002/mus.24569 |
| Journal | Muscle & Nerve |
| Issue Number | 4 |
| Volume Number | 52 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-03-31 |
| Access Restriction | Open |
| Subject Keyword | Journal: Muscle & Nerve Facioscapulohumeral Muscular Dystrophy Radiographic Biomarkers Whole-body Imaging |
| Content Type | Text |
| Resource Type | Article |
