NDLI: beta-Amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

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beta-Amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

Content Provider	Scilit
Author	Wickham, Louise Benjannet, Suzanne Marcinkiewicz, Edwige Chretien, Michel Seidah, Nabil G.
Copyright Year	2005
Description	Journal: Journal of Neurochemistry Using a yeast two-hybrid system, we screened a human brain cDNA library for possible interacting proteins with the C-terminal cytosolic tail of the beta-secretase beta-amyloid protein converting enzyme (BACE)1. This identified seven potential candidates, including the brain-specific type II membrane protein BRI3. Co-localization and co-immunoprecipitation experiments confirmed that BACE1 and BRI3 co-localize and interact with each other via the cytosolic tail of BACE1. Furthermore, pulse and pulse-chase analyses revealed that the pro-protein convertases furin, and to a lesser extent PC7 and PC5A, process BRI3 into a C-terminal secreted approximately 4-kDa product. Thus, furin efficiently processes both pro-BACE1 and its novel interacting protein pro-BRI3.
Ending Page	102
Starting Page	93
ISSN	2573508X
e-ISSN	14714159
DOI	10.1111/j.1471-4159.2004.02840.x
Journal	Journal of Neurochemistry
Issue Number	1
Volume Number	92
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2005-01-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Neurochemistry Biochemistry and Molecular Biology Cell Biology Amyloid Precursor Protein Beta Secretase Binding Partners Cytosolic Tail Two‐hybrid System
Content Type	Text
Resource Type	Article

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