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Encapsulation for Somatic Gene Therapy
| Content Provider | Scilit |
|---|---|
| Author | Chang, Patricia L. |
| Copyright Year | 1999 |
| Description | Journal: Annals of the New York Academy of Sciences With the human genome project approaching its completion date of 2005, gene‐based technology will play an increasingly important role in health‐care delivery. Non‐autologous somatic gene therapy is a novel application in which non‐autologous cell lines engineered to secrete a recombinant protein are enclosed within immunoisolation devices and implanted into all patients requiring the same product for therapy. The development of this technology requiers a multi‐disciplinary effort towards optimization of the biomaterial used to manufacture the implantable devices and selection of the aporopriate cell lines for enclosure. The efficacy of this technology is illustrated in the treatment of dwarfism and lysosomal storage disease in murine models. The potential of a safe and cost‐effective gene‐based delivery method should have wide applications in treating both classical genetic disorders and non‐mendelian diseases. |
| Related Links | https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.1999.tb08500.x |
| Ending Page | 158 |
| Page Count | 13 |
| Starting Page | 146 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.1999.tb08500.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 875 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1999-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Cell Tissue Engineering Biomedical Engineering |
| Content Type | Text |
| Resource Type | Article |
