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Barrier Effects of Nutritional Factors
| Content Provider | Scilit |
|---|---|
| Author | Amasheh, Maren Andres, Susanne Amasheh, Salah Fromm, Michael Schulzke, Jörg-Dieter |
| Copyright Year | 2009 |
| Description | Journal: Annals of the New York Academy of Sciences High dietary intake of fruits and vegetables is associated with a reduced disease risk. Therefore, clinical interest is growing in therapies based on dietary supplements and effects of food components. Immune-modulatory and barrier-protective effects have been described for the amino acid glutamine and the trace element zinc. In Caco-2-cells, zinc is necessary to maintain the expression of proteins like ZO-1 and occludin, and experimental evidence exists that glutamine has enterocyte-protective effects and modulates intestinal barrier function in stressed animals and humans. Polyunsaturated fatty acids (PUFA) improve paracellular permeability after IL-4 incubation. Enhancement of barrier properties by long-chain PUFA is discussed controversially, but a beneficial role preventing the redistribution of occludin and ZO-1 and reduction of epithelial resistance by IFN-gamma and TNF-alpha exists. In addition, a group of secondary plant compounds, the polyphenols, are supposed to be important in this respect. The flavonoid quercetin and its metabolite DHBA increased epithelial resistance of Caco-2-cells to 157 +/- 4% of control values, and DHBA up to 119 +/- 4% of control values, respectively. This is due to a 2.3 +/- 0.1-fold expression rate of the tight junction protein claudin-4. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04063.x/pdf |
| Ending Page | 273 |
| Page Count | 7 |
| Starting Page | 267 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.2009.04063.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 1165 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Nutrition and Dietetics |
| Content Type | Text |
| Resource Type | Article |
