NDLI: Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy

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Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy

Content Provider	Scilit
Author	Karol, Seth E. Coustan-Smith, Elaine Cao, Xueyuan Shurtleff, Sheila A. Raimondi, Susana C. Choi, John K. Ribeiro, Raul C. Dahl, Gary V. Bowman, William Paul Taub, Jeffrey W. Degar, Barbara Leung, Wing Downing, James R. Pui, Ching-Hon Rubnitz, Jeffrey E. Campana, Dario Inaba, Hiroto
Copyright Year	2014
Description	Journal: British Journal of Haematology Minimal residual disease (MRD) is a strong prognostic factor in children and adolescents with acute myeloid leukaemia (AML) but nearly one-quarter of patients who achieve MRD-negative status still relapse. The adverse prognostic factors among MRD-negative patients remain unknown. We analysed the AML02 study cohort to identify demographic and genetic prognostic factors. Among the presenting features, certain 11q23 abnormalities, such as t(6;11) and t(10;11), acute megakaryoblastic leukaemia without the t(1;22), and age ≥10 years were associated with inferior outcome in patients who had MRD-negative status after either remission induction I or II. By contrast, those with rearrangement of CBF genes had superior outcome. Our study identifies patient populations for whom close post-remission MRD monitoring to detect and treat emerging relapse and adjustment in treatment intensity might be indicated.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262553/pdf
e-ISSN	13652141
DOI	10.1111/bjh.13107
Journal	British Journal of Haematology
Issue Number	1
Volume Number	168
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-08-28
Access Restriction	Open
Subject Keyword	Journal: British Journal of Haematology Acute Myeloid Leukaemia Minimal Residual Disease Prognostic Factor
Content Type	Text
Resource Type	Article

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