NDLI: In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease

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In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease

Content Provider	Scilit
Author	Khodabukus, Alastair Prabhu, Neel Wang, Jason Bursac, Nenad
Copyright Year	2018
Description	Journal: Advanced Healthcare Materials Healthy skeletal muscle possesses the extraordinary ability to regenerate in response to small‐scale injuries; however, this self‐repair capacity becomes overwhelmed with aging, genetic myopathies, and large muscle loss. The failure of small animal models to accurately replicate human muscle disease, injury and to predict clinically‐relevant drug responses has driven the development of high fidelity in vitro skeletal muscle models. Herein, the progress made and challenges ahead in engineering biomimetic human skeletal muscle tissues that can recapitulate muscle development, genetic diseases, regeneration, and drug response is discussed. Bioengineering approaches used to improve engineered muscle structure and function as well as the functionality of satellite cells to allow modeling muscle regeneration in vitro are also highlighted. Next, a historical overview on the generation of skeletal muscle cells and tissues from human pluripotent stem cells, and a discussion on the potential of these approaches to model and treat genetic diseases such as Duchenne muscular dystrophy, is provided. Finally, the need to integrate multiorgan microphysiological systems to generate improved drug discovery technologies with the potential to complement or supersede current preclinical animal models of muscle disease is described.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105407/pdf
e-ISSN	21922659
DOI	10.1002/adhm.201701498
Journal	Advanced Healthcare Materials
Issue Number	15
Volume Number	7
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2018-08-01
Access Restriction	Open
Subject Keyword	Journal: Advanced Healthcare Materials Biomedical Engineering Disease Modeling Induced Pluripotent Stem Cells Skeletal Musclemuscular Dystrophy Tissue Engineering
Content Type	Text

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