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Original Article: Highly conserved cross-reactive CD4+ T-cell HA-epitopes of seasonal and the 2009 pandemic influenza viruses
| Content Provider | Scilit |
|---|---|
| Author | Duvvuri, Venkata R. S. K. Moghadas, Seyed M. Guo, Hong Bin Duvvuri, Bhargavi Heffernan, Jane M. Fisman, David N. Wu, Gillian E. Wu, Jianhong |
| Copyright Year | 2010 |
| Description | Journal: Influenza and Other Respiratory Viruses The relatively mild nature of the 2009 influenza pandemic (nH1N1) highlights the overriding importance of pre-existing immune memory. The absence of cross-reactive antibodies to nH1N1 in most individuals suggests that such attenuation may be attributed to pre-existing cellular immune responses to epitopes shared between nH1N1 virus and previously circulating strains of inter-pandemic influenza A viruses. We sought to identify potential CD4+ T cell epitopes and predict the level of cross-reactivity of responding T cells. By performing large-scale major histocompatibility complex II analyses on Hemagglutinin (HA) proteins, we investigated the degree of T-cell cross-reactivity between seasonal influenza A (sH1N1, H3N2) from 1968 to 2009 and nH1N1 strains. Each epitope was examined against all the protein sequences that correspond to sH1N1, H3N2, and nH1N1. T-cell cross-reactivity was estimated to be 52%, and maximum conservancy was found between sH1N1 and nH1N1 with a significant correlation (P < 0.05). Given the importance of cellular responses in kinetics of influenza infection in humans, our findings underscore the role of T-cell assays for understanding the inter-pandemic variability in severity and for planning treatment methods for emerging influenza viruses. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634651/pdf |
| Ending Page | 258 |
| Page Count | 10 |
| Starting Page | 249 |
| e-ISSN | 17502659 |
| DOI | 10.1111/j.1750-2659.2010.00161.x |
| Journal | Influenza and Other Respiratory Viruses |
| Issue Number | 5 |
| Volume Number | 4 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-08-17 |
| Access Restriction | Open |
| Subject Keyword | Journal: Influenza and Other Respiratory Viruses Influenza A/h1n1 Mhc Ii Pandemic Dynamics Pre‐existing Immunity T‐cell Cross‐reactivity |
| Content Type | Text |
| Resource Type | Article |
