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Influence of biphasic calcium phosphate granulometry on bone ingrowth, ceramic resorption, and inflammatory reactions: Preliminaryin vitro andin vivo study
| Content Provider | Scilit |
|---|---|
| Author | Malard, Olivier Bouler, Jean Michel Heymann, Dominique Pilet, Paul Daculsi, Guy |
| Copyright Year | 1999 |
| Description | Journal: Journal of biomedical materials research Calcium-phosphate ceramics used in surgery, as bone-bonding materials, are currently available in different forms (blocks, granules, etc.). However, progress in noninvasive surgery has favored the development of injectable composite materials associating a polymeric and a dusty mineral phase. The purpose of this study was the in vivo evaluation of biphasic calcium phosphate of various grains sizes, to elucidate the role of granulometries in ceramic degradation/resorption, bone ingrowth, and inflammatory reactions. Three particle sizes were compared: 10–20, 80–100, and 200–400 μm. The 10–20-μm powders provided the best bone ingrowth, with a higher resorption/degradation rate in conjunction with stronger early inflammatory reactions. The 200–400-μm powders showed higher bone ingrowth than 80–100-μm ones, indicating that properties of cell recruitment for osseous apposition and mechanical support for bone bonding may both play a role in both ingrowth mechanisms. Our results suggest that the strong inflammatory reaction in 10–20-μm granulated powders was due to a faster reversal of the resorption/apposition sequence in bone. This may have resulted from massive release of bone ingrowth factors, which implies that the brief inflammatory process observed in the early stages of implantation was favorable to the osteoconduction process. © 1999 John Wiley & Sons, Inc. J Biomed Mater Res, 46, 103–111, 1999. |
| Related Links | https://onlinelibrary.wiley.com/doi/pdf/10.1002/(SICI)1097-4636(199907)46:1<103::AID-JBM12>3.0.CO;2-Z |
| Ending Page | 111 |
| Page Count | 9 |
| Starting Page | 103 |
| ISSN | 00219304 |
| e-ISSN | 10974636 |
| DOI | 10.1002/%28sici%291097-4636%28199907%2946%3A1%3C103%3A%3Aaid-jbm12%3E3.0.co%3B2-z |
| Journal | Journal of biomedical materials research |
| Issue Number | 1 |
| Volume Number | 46 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1999-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of biomedical materials research Biomedical Engineering Biphasic Calcium Phosphate Ceramic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biomedical Engineering |
