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Ketamine/Propofol Versus Midazolam/Fentanyl for Procedural Sedation and Analgesia in the Emergency Department: A Randomized, Prospective, Double-Blind Trial
| Content Provider | Scilit |
|---|---|
| Author | Nejati, Amir Moharari, Reza Shariat Ashraf, Haleh Labaf, Ali Golshani, Keihan |
| Copyright Year | 2011 |
| Description | Journal: Academic Emergency Medicine The authors performed a prospective, double-blinded, randomized trial with emergency department (ED) patients requiring procedural sedation and analgesia (PSA) for repair of deep traumatic lacerations and reduction of bone fractures, to compare the ketamine/propofol (ketofol) combination with the midazolam/fentanyl (MF) combination. Sixty-two patients scheduled for PSA who presented between January 2009 and June 2009 were enrolled prospectively. Thirty-one were randomly assigned to the ketofol group, and 31 were assigned to the MF group. The median starting doses were 0.75 mg/kg of both ketamine and propofol (interquartile range [IQR] = 0.75 to 1.5 mg/kg), 0.04 mg/kg midazolam (IQR = 0.04 to 0.06 mg/kg), and 2 μg/kg fentanyl (IQR = 2 to 3 μg/kg). There were no significant differences in sedation time between the groups. There were no differences in physician satisfaction (p = 0.065). Perceived pain in the ketofol group, as measured by the Visual Analog Scale (VAS), was significantly lower than in the MF group (median ketofol = 0, IQR = 0-1 vs. median MF = 3, IQR = 1-6; p < 0.001). Only one patient in each group required bag-mask ventilation, and neither of them were intubated. The ketamine/propofol combination provides adequate sedation and analgesia for painful procedures and appears to be a safe and useful technique in the ED. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1553-2712.2011.01133.x/pdf |
| Ending Page | 806 |
| Page Count | 7 |
| Starting Page | 800 |
| ISSN | 10696563 |
| e-ISSN | 15532712 |
| DOI | 10.1111/j.1553-2712.2011.01133.x |
| Journal | Academic Emergency Medicine |
| Issue Number | 8 |
| Volume Number | 18 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2011-08-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Academic Emergency Medicine Emergency Medicine Ketamine/propofol |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine |
