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Sandwich Radioimmunometric Assay with Murine Monoclonal Antibody, NCC-ST-439, for Serological Diagnosis of Human Cancers
| Content Provider | Scilit |
|---|---|
| Author | Sugano, Kokichi Ohkura, Hisanao Maruyama, Takashi Watanabe, Masahiko Hirohashi, Setsuo Shimosato, Yukio Kodaira, Susumu Abe, Osahiko |
| Copyright Year | 1988 |
| Description | Journal: Japanese Journal of Cancer Research Sandwich radioimmunometric assay (RIA) for a new tumor‐associated carbohydrate antigen defined by a monoclonal antibody (MoAb), NCC‐ST‐439, was developed and the antigen levels were determined in sera of normal donors, and patients with various malignant and non‐malignant disorders. In normal donors, 97.0% (226/233) of sera were antigen‐negative (less than 12 units/ml) except for 7 serum samples from young females. In patients with malignant disorders, 34.2% (82/240) were antigen‐positive, in particular 64.0% (16/25) of patients with pancreatic carcinoma, 66.7% (16/24) of patients with recurrent colorectal carcinoma and 54,5% (6/11) of patients with recurrent breast carcinoma. In patients with non‐malignant disorders, 6.0% (7/116) were antigen‐positive. The positive rate in benign hepatobiliary disorders, including gallstones, hepatitis and liver cirrhosis, was especially low at 4.3% (1/23). We concluded that determination of serum NCC‐ST‐439 antigen would be useful in serodiagnosis of carcinoma patients. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917558/pdf http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.1988.tb00031.x/pdf |
| Ending Page | 625 |
| Page Count | 8 |
| Starting Page | 618 |
| ISSN | 09105050 |
| DOI | 10.1111/j.1349-7006.1988.tb00031.x |
| Journal | Japanese Journal of Cancer Research |
| Issue Number | 5 |
| Volume Number | 79 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1988-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Japanese Journal of Cancer Research Gastroenterology and Hepatology Monoclonal Antibody Sandwich Radioimmunometric Assay Tumor‐associated Carbohydrate Antigen |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
