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Effects of Acute Toxic Doses of Psychostimulants on Extracellular Levels of Excitatory Amino Acids and Taurine in Rats
| Content Provider | Scilit |
|---|---|
| Author | Anderzhanova, E. Rayevsky, K. S. Saransaari, P. Riitamaa, E. Oja, S. S. |
| Copyright Year | 2006 |
| Description | Journal: Annals of the New York Academy of Sciences We used microdialysis to study how acute toxic doses of d-amphetamine and sydnocarb [3-(beta-phenylisopropyl)-N-phenylcarbamoylsydnonimine], an original Russian psychostimulant, affect extracellular levels of glutamate, aspartate, and taurine in the neostriatum of halothane-anesthetized male Sprague-Dawley rats. The administration of d-amphetamine (5.0 mg/kg x 4 i.p.) caused gradual fivefold increases in the extracellular glutamate and taurine levels and moderate increases in the extracellular aspartate level. Sydnocarb administration (23.8 mg/kg x 4 i.p., a dose equimolar to 5.0 mg/kg d-amphetamine) elicited a marked increase in the extracellular aspartate level and a small increase in the extracellular level of glutamate. The extracellular taurine level increased only after the last (fourth) injection. We conclude that a massive increase in extracellular taurine reflects hyperactivation of glutamatergic neurotransmission elicited by acute toxic dose of d-amphetamine. Sydnocarb seems to be less neurotoxic than d-amphetamine, because it elicits lesser changes in the extracellular levels of glutamate and taurine. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2002.tb04161.x/pdf |
| Ending Page | 203 |
| Page Count | 11 |
| Starting Page | 193 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.2002.tb04161.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 965 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2006-01-24 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences |
| Content Type | Text |
| Resource Type | Article |
