Loading...
Please wait, while we are loading the content...
Similar Documents
Cerebral metabolic rate of oxygen $(CMRO_{2}$) mapping by combining quantitative susceptibility mapping (QSM) and quantitative blood oxygenation level-dependent imaging (qBOLD)
| Content Provider | Scilit |
|---|---|
| Author | Cho, Junghun Kee, Youngwook Spincemaille, Pascal Nguyen, Thanh D. Zhang, Jingwei Gupta, Ajay Zhang, Shun Wang, Yi |
| Copyright Year | 2018 |
| Description | Journal: Magnetic Resonance in Medicine To map the cerebral metabolic rate of oxygen $(CMRO_{2}$) by estimating the oxygen extraction fraction (OEF) from gradient echo imaging (GRE) using phase and magnitude of the GRE data. 3D multi-echo gradient echo imaging and perfusion imaging with arterial spin labeling were performed in 11 healthy subjects. $CMRO_{2}$ and OEF maps were reconstructed by joint quantitative susceptibility mapping (QSM) to process GRE phases and quantitative blood oxygen level-dependent (qBOLD) modeling to process GRE magnitudes. Comparisons with QSM and qBOLD alone were performed using ROI analysis, paired t-tests, and Bland-Altman plot. The average $CMRO_{2}$ value in cortical gray matter across subjects were 140.4 ± 14.9, 134.1 ± 12.5, and 184.6 ± 17.9 μmol/100 g/min, with corresponding OEFs of 30.9 ± 3.4%, 30.0 ± 1.8%, and 40.9 ± 2.4% for methods based on QSM, qBOLD, and QSM+qBOLD, respectively. QSM+qBOLD provided the highest $CMRO_{2}$ contrast between gray and white matter, more uniform OEF than QSM, and less noisy OEF than qBOLD. Quantitative $CMRO_{2}$ mapping that fits the entire complex GRE data is feasible by combining QSM analysis of phase and qBOLD analysis of magnitude. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097883/pdf |
| Ending Page | 1604 |
| Page Count | 10 |
| Starting Page | 1595 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.27135 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 4 |
| Volume Number | 80 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2018-03-07 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Cerebral Metabolic Rate of Oxygen Quantitative Blood Oxygenation Level‐dependent Imaging Quantitative Susceptibility Mapping |
| Content Type | Text |
| Resource Type | Article |