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Sensitivity of arterial spin labeling perfusion MRI to pharmacologically induced perfusion changes in rat kidneys

Content Provider	Scilit
Author	Tan, Huan Thacker, Jon Franklin, Tammy Prasad, Pottumarthi V.
Copyright Year	2014
Description	Journal: Journal of Magnetic Resonance Imaging (JMRI) To investigate whether arterial spin labeling (ASL) MRI is sensitive to changes by pharmacologically induced vasodilation and vasoconstriction in rat kidneys. Changes in renal cortical blood flow in seven rats were induced by adenosine infusion (vasodilation) and L-NAME injection (vasoconstriction). All imaging studies were performed on a 3 Tesla scanner using a FAIR-TrueFISP sequence for the ASL implementation. The acquisition time for each ASL scan was 6 min. Cortical perfusion rates were calculated using regions of interest analysis, and the differences in perfusion rates during baseline, vasodilation, and vasoconstriction were compared and assessed for statistical significance. Compared with the baseline, an average of 94 mL/100 g/min increase and 157 mL/100 g/min decrease in cortical perfusion was observed following adenosine infusion and L-NAME administration, respectively. The changes in cortical perfusion were significant between baseline and vasodilation (P < 0.05), baseline and vasoconstriction (P < 0.01), and vasodilation and vasoconstriction (P < 0.01). ASL is sensitive to pharmacologically induced perfusion changes in rat kidneys at doses comparable to current use. The preliminary results suggest the feasibility of ASL for investigating renal blood flow in a variety of rodent models.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223005/pdf
Ending Page	1128
Page Count	5
Starting Page	1124
e-ISSN	15222586
DOI	10.1002/jmri.24645
Journal	Journal of Magnetic Resonance Imaging (JMRI)
Issue Number	4
Volume Number	41
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-05-06
Access Restriction	Open
Subject Keyword	Journal: Journal of Magnetic Resonance Imaging (JMRI) Radiology, Nuclear Medicine and Imaging
Content Type	Text
Resource Type	Article

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