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Local Regulation of L-Type Ca2+Channel Sparklets in Arterial Smooth Muscle
| Content Provider | Scilit |
|---|---|
| Author | Navedo, Manuel F. Amberg, Gregory C. |
| Copyright Year | 2013 |
| Description | Journal: Microcirculation This review addresses the latest advances in our understanding of the regulation of a novel Ca²⁺ signal called L-type Ca²⁺ channel sparklets in arterial smooth muscle. L-type Ca²⁺ channel sparklets are elementary Ca²⁺ influx events produced by the opening of a single or a small cluster of L-type Ca²⁺ channels. These Ca²⁺ signals were first visualized in the vasculature in arterial smooth muscle cells. In these cells, L-type Ca²⁺ channel sparklets display two functionally distinct gating modalities that regulate local and global [Ca²⁺](i). The activity of L-type Ca²⁺ channel sparklets varies regionally within a cell depending on the dynamic activity of a cohort of protein kinases and phosphatases recruited to L-type Ca²⁺ channels in the arterial smooth muscle sarcolemma in a complex coordinated by the scaffolding molecule AKAP150. We also described a mechanism whereby clusters of L-type Ca²⁺ channels gate cooperatively to amplify intracellular Ca²⁺ signals with likely pathological consequences. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577995/pdf |
| Ending Page | 298 |
| Page Count | 9 |
| Starting Page | 290 |
| e-ISSN | 15498719 |
| DOI | 10.1111/micc.12021 |
| Journal | Microcirculation |
| Issue Number | 4 |
| Volume Number | 20 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2013-05-10 |
| Access Restriction | Open |
| Subject Keyword | Journal: Microcirculation Arterial Smooth Muscle Channel Sparklets Type Ca |
| Content Type | Text |
| Resource Type | Article |
