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Sphingosine-1-Phosphate as an Intercellular Signaling Moleculea
| Content Provider | Scilit |
|---|---|
| Author | Igarashi, Yasuyuki |
| Copyright Year | 1998 |
| Description | Journal: Annals of the New York Academy of Sciences Sphingosine-1-phosphate (Sph-1-P) has been implicated as an intracellular second messenger in many studies. Previously, we found the roles of Sph-1-P as a platelet activating lipid released from stimulated platelets and as a lipid regulator of cell motility. We first investigated the mechanism by which Sph-1-P induces activation in platelets. Although exogenous Sph-1-P activated platelets, intracellular Sph-1-P formed from exogenously added Sph failed to do so. Supporting the notion that exogenous Sph-1-P stimulates platelets from outside, we found that contact of platelet surfaces with Sph-1-P-immobilized glass beads resulted in platelet activation. Using these glass beads, we next found that exogenously added Sph-1-P inhibits F10 cell motility from outside through its specific binding site(s) on the cell. We finally identified putative receptor protein(s) for Sph-1-P on the surface of F10 cells. |
| Related Links | https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.1998.tb09659.x |
| Ending Page | 31 |
| Page Count | 13 |
| Starting Page | 19 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.1998.tb09659.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 SPHINGOL |
| Volume Number | 845 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1998-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences |
| Content Type | Text |
| Resource Type | Article |
