Loading...
Please wait, while we are loading the content...
Similar Documents
Variation in serum prostate-specific antigen levels in men with prostate cancer managed with active surveillance
| Content Provider | Scilit |
|---|---|
| Author | Ehdaie, Behfar Poon, Bing Ying Sjoberg, Daniel D. Recabal, Pedro Laudone, Vincent Touijer, Karim Eastham, James Scardino, Peter T. |
| Copyright Year | 2015 |
| Description | Journal: BJU International To describe fluctuations in prostate-specific antigen (PSA) levels in men managed with active surveillance (AS) to determine if a single PSA increase is a consistent measure to use to trigger intervention. We evaluated data on 541 patients undergoing AS between 1995 and 2011. PSA variation was described by studying the Kaplan-Meier probability of patients' PSA levels reaching 4 or 7 ng/mL, falling below those thresholds, and then rising to those thresholds again. We also examined PSA variation by calculating the Kaplan-Meier probability of a PSA change followed by an equal or greater change in the opposite direction. We analysed data on 541 patients undergoing AS with a median (interquartile range [IQR]) of 8 (6-12) PSA measurements and undergoing AS for a median (IQR) of 4 (2-6) years. The 5-year estimate of the probability of reaching a threshold PSA of 7 ng/mL was 40% (95% confidence interval [CI] 35-46%) and the 5-year estimate of subsequently falling below this threshold was 90% (95% CI 82-95%). The 5-year estimate of a PSA direction change was 95% (95% CI 93-97%) overall and 56% (95% CI 51-61%) for PSA direction changes of ≥1 ng/mL. We observed a high probability of variability in PSA levels for patients on AS. The probability of changes in PSA, defined by an increase to the specified thresholds or a rise >1 ng/mL within 6 months and subsequent decrease of equal or greater value on a subsequent measurement, increases over time; therefore, a single change in PSA level is not a reliable endpoint for patients on AS. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523832/pdf |
| Ending Page | 540 |
| Page Count | 6 |
| Starting Page | 535 |
| e-ISSN | 1464410X |
| DOI | 10.1111/bju.13328 |
| Journal | BJU International |
| Issue Number | 4 |
| Volume Number | 118 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-10-26 |
| Access Restriction | Open |
| Subject Keyword | Journal: BJU International Primary Health Care Active Surveillance Prostate Cancer Prostate Specific Antigen |
| Content Type | Text |
| Resource Type | Article |
