NDLI: Characterization of the anti-CD22 targeted therapy, moxetumomab pasudotox, for B-cell precursor acute lymphoblastic leukemia

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Characterization of the anti-CD22 targeted therapy, moxetumomab pasudotox, for B-cell precursor acute lymphoblastic leukemia

Content Provider	Scilit
Author	Kinjyo, Ichiko Matlawska-Wasowska, Ksenia Chen, Xiaoru Monks, Noel R. Burke, Patricia Winter, Stuart S. Wilson, Bridget S.
Copyright Year	2017
Description	Journal: Pediatric Blood & Cancer Moxetumomab pasudotox is a second-generation recombinant immunotoxin against CD22 on B-cell lineages. Antileukemic activity has been demonstrated in children with chemotherapy-refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL), with variable responses. Here, we report in vitro and in vivo evaluation of moxetumomab pasudotox treatment of human cell lines and patient-derived cells as a preliminary study to understand characteristics of sensitivity to treatment. Binding, internalization, and apoptosis were evaluated using fluorescently tagged moxetumomab pasudotox. Studies in NOD-scid IL2Rgnull mice showed a modest survival benefit in mice engrafted with 697 cells but not in NALM6 or the two patient-derived xenograft models.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501879/pdf
e-ISSN	15455017
DOI	10.1002/pbc.26604
Journal	Pediatric Blood & Cancer
Issue Number	11
Volume Number	64
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2017-04-27
Access Restriction	Open
Subject Keyword	Journal: Pediatric Blood & Cancer Acute Lymphoblastic Leukemia
Content Type	Text
Resource Type	Article

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