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Somatic mutation of MutYH in Tunisian patients with sporadic colorectal cancer
| Content Provider | Scilit |
|---|---|
| Author | Bougatef, Karim Marrakchi, Raja Kourda, Nadia Lahely, Yannick Blondeau Jileni, Sarra Baltagi Ben Khil, Houssein K. El Soubrier, Florent Elgaaied, Amel Ben Ammar |
| Copyright Year | 2007 |
| Description | Journal: Journal of Clinical Laboratory Analysis The MutYH gene is an adenine-specific DNA glycosylase that prevents G/T transversions. Germline mutation in this gene causes MYH-associated polyposis (MAP) that predispose to hereditary colorectal cancer (CRC). This study describes for the first time the association of the MutYH mutation with sporadic CRC. From the 48 Tunisian sporadic CRC cases analyzed, two patients showed somatic mutation of the MutYH gene. In addition, the two hotspot germline mutations MutYH Y165C and G382D seem to be infrequent in sporadic CRC. J. Clin. Lab. Anal. 21:372–374, 2007. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649000/pdf |
| Ending Page | 374 |
| Page Count | 3 |
| Starting Page | 372 |
| e-ISSN | 10982825 |
| DOI | 10.1002/jcla.20198 |
| Journal | Journal of Clinical Laboratory Analysis |
| Issue Number | 6 |
| Volume Number | 21 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2007-11-16 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Clinical Laboratory Analysis Gastroenterology and Hepatology Myh-associated Polyposis |
| Content Type | Text |
| Resource Type | Article |
